Should I just ask for this to be done regardless? Your post will be hidden and deleted by moderators. When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Reply Share React operationpepper Dec 22, 2015 3:42 PM Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? Best of luck to you with your upcoming FET, my thoughts and prayers are with you! Have they tried changing your protocol (ie from natural to artificial cycle)? I dont see myself spending a fortune on acupuncture again. If your window is off I would think that could cause chemical pregnancies because the embryo would have a hard time implanting. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. 2 - IVF BFN Its such a good point and one that is often missed, I think. Preliminary studies examine the rebiopsy and transfer of chaotic embryos by PGT-A. My dr never mentioned anything regarding epigenetic issues. I honestly wish I had but thats all hindsight now knowing what I knew. We had 30 eggs retrieval. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Did our first FET in October with a supposedly PGT normal embryo. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. Im very sorry and hope you can find the strength to continue. Its good you will request the endomitritis biopsy. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. But it seems like the majority of twin pregnancies result in healthy babies. For more background info, check out my post onPGS Testing. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. Going into my second round of IVF I was doubting anything would work. Does it still matter? I agree with the others that you should push for some sort of testing or SOMETHING to investigate before trying again (if you haven't already). Your story does give me hope and I wish my little one is as strong as yours! I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this! Sending you lots of love, hope and positivity! I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. thank you so much! 1) Has anyone else had the immune suppressing protocol NOT work, and then gone on to have it work? Check here for the full. So weve been ttc for almost 2 years. We have one day 7/Euploid Blast 5BB remaining on ice. MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). Use of this site is subject to our terms of use and privacy policy. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. Wishing you the best of luck and baby dust. Currently 8 weeks. Im so sorry to hear about your losses but so happy with your current miracle. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. Another study agrees with these data (Franasiak et al. Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? How did your pregnancy turn out? She is pregnant right now from that cycle. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. Theper retrievalstatistic helps to see the chancesbefore PGStesting. My doctor thought it was possibly due to retained products of conception. Both Chemical pregnancies my lining was under 7. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. Thankful for these forums! We started some workup with my OB (TSH, karyotyping and carrier testing). How does anyone not go completely crazy through this whole process???? Pgs testing - how many normal? - Infertility - Inspire Endomitritis is basically an inflammation in the uterus that makes it inhospitable for an embryo to implant or grow. Infertility Support Community in Partnership with RESOLVE. Ill have to ask my RE for options. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). END MENTS. Gearing up for FET I can't tell if that is from the progesterone. Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. You can check out my summary of the study here. How IVF with PGS is Changing the Fertility Game for Women over Age 35 I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. I want to be exhaustive in testing to get to the bottom of the issue, but I certainly don't want to waste time/money on tests we don't need. MENTS my 3rd FET was a success end MENTS. Feeling more confused than ever. At least testing a few variables like blood clotting. My first FET failed and it was devastating. I encourage to keep pushing forward. It took me 3 fresh + 3 frozen but I finally did get my baby. 2) I feel like I've turned over every stone in trying to figure out what is wrong; does anyone have insight into how one would determine whether the problem is with the egg or with my body? Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. We strive to provide you with a high quality community experience. However, theirsample sizewas small. It had an extra chromosome from the sperm and another from the egg. Thats what i needed to hear. Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . It definitely won't hurt to ask your doctors about an antihistamine protocol, I don't remember the exact dosages I took or how long. Normal Embryo Success Rate: RMA Research Study Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. Question about blastocysts and PGS testing - we got 12 eggs / 7 mature / 7 fertilized with ICSI and 2 grew to 6 days. It was a chemical pregnancy. All the comments on here seem pretty helpful already. yes! A chemical pregnancy is a very early miscarriage that happens within the first five weeks of pregnancy. 8 Things I've Learned From 4 Failed IVF Cycles - SELF I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. Your clinic may have a better idea! Wishing you lots of luck. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. I had a chemical pregnancy with my first FET. I paid a fortune for those sessions (I dont have insurance). Go figure, right?! Neal et al. I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. definitely worth asking! Best of luck to you. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . Why I Gave My Mosaic Embryo a Chance - The New York Times Best of luck to you!! (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. PGS Normal FET Results in Chemical Pregnancy *with* autoimmune protocol, Need some Love!!! He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Hopefully an ERA can shed some light on it! I just officially confirmed another Chemical pregnancy for me. PGS (PGT-A) success rates - PGS Testing (PGT-A) - Remembryo Might be worth asking about. Chemical Pregnancy: Causes, Symptoms & Treatment - Cleveland Clinic Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. I just don't know what to do. If your protocol did not have one or the other perhaps you can ask your RE about it. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. A recent meta-analysis by Simopoulou et al. MENTS THROUGHOUT MENTS I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. I know Ive had issues with my lining but for each of the chemical pregnancies we were able to get my lining to at least 8mm with a mixture of puregon and cetrotide injections, instead of estrace, as well as PRPs. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. 2 - IUIs both chemical Single embryo transfer both times. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). They also did a subgroup analysis using this data for age groups <35 and >35. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. Hi Mogwai_2 Theses are rates for PGS normal embryos. Obviously this is not an ideal situation but sometimes this happens. Jun 13, 2021 2:33 PM It is looking like we will have a second consecutive blighted ovum with a PGS normal embryo. I know how devastating loss can be but theres always, always hope. Yes, and I believe it was due to doctor negligence. The usefulness comes when someone who is starting IVF and considering PGS testing. They havent discontinued my medication they want me to continue until further instructions. I'm curious if this might have something to do with it. Liebermann et al. Thanks so much in advance for any feedback. The Munne et al. 12 43 comments Best Add a Comment gundacurry 2 yr. ago https://www.fertstert.org/article/S0015-0282 (17)31371-7/fulltext lennylincs 2 yr. ago (2017)had similar results to above (aCGH, women <35): Capalbo et al. Mosaics are embryos that have a mix of euploid and aneuploid cells. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. Any advice is greatly appreciated. thank you for sharing! I feel like your doctor should have mentioned the ERA and biopsy by now. thats a great suggestion! Or is it worth having the actual tests done? Viotti et al. Find advice, support and good company (and some stuff just for fun). The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Have you ever had an endometrial biopsy to look for infection? Try to take extra good care of yourself while you regroup from this cycle, and then go with your instincts for your next cycle. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. I hope the ERA works too. Dogpark in reply to Mogwai_2 3 years ago. (The embryo split!) hang in there. I was wondering what protocol were you on for your second transfer? The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. I was doing yoga and walking everyday and meditating. The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. What is the percentage of PGT normal embryos after 40 - Reddit In large scale Double Blind Randomized Control Trials (the best method for medical protocol research) PGT did not increase your chances of pregnancy, except in some scenarios. Best of luck! I also am interested in doing an endo scratch beforehand and adding Viagra if the shots and scratch aren't doing the job. We got to see and hear the heartbeat yesterday. I will ask my dr about this. Every positive thing helps! No additional testing has been offered after 3 chemicals and one failed implantation on PGS normal embryos - he just tries to push me onto surrogacy each time saying sometimes thats the only option. However we now understand that the chromosomes are only part of the issue. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. I feel like most times the protocol for autoimmune issues is the same. Im surprised there are still doctors out there who do not bring up this protocol. Consult with your doctor before making any treatment changes. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. I think whats missing is the success rates for transfers of non PGS tested embryos. Will be put on lovenox this round as well. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. So sorry this happened and good luck to you. Early Pregnancy Loss - Miscarriage Doctor in Los Angeles - USC Fertility Besides that, there are no gaurantees of both sticking. Im sorry to hear of your loss! Do you think it's worth it as last time I had a medicated cycle and it was a . Terms are highlighted every 3rd time to avoid repetition.
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