This article can shed light on the details. Blood. There are no funding sources associated with the writing of this manuscript. He saw his physician and she suspected some type of internal bleeding based on the blood test, He had an upper and lower endoscopy. performed research, collected and analyzed data, and wrote the first draft of the manuscript; X.Y. Three patients developed counts below 30,000 with purpuric symptoms and needed treatment that consisted in two courses of dexamethasone 40 mg daily for four days every three weeks; all patients reached complete remission without any further treatment. "Good afternoon and welcome to Mayo Connect. Accessibility My husband gives blood regularly. Appendix ASupplementary data to this article can be found online at https://doi.org/10.1016/j.jaut.2021.102782. (2021). Further epidemiological evaluations of the incidence of AA after COVID-19 infection and SARS-CoV-2 vaccination are warranted. Twenty-three patients with autoimmune thrombocytopenia did not develop any fall in the platelet count. staining (x40) of the bone marrow after the administration of a SARS-CoV-2 vaccine showed a markedly hypocellular marrow. Akrami M, Hosamirudsari H, Faraji N, Behnush B, Goudarzi F, Hesari E, Akbarpour S, Najafi A, Nateghi S. Indian J Med Microbiol. So far, most reports of COVID-19 with anemia have been in hospitalized individuals. The https:// ensures that you are connecting to the While it can take up to 10-14 years for a vaccine to be 2023 Apr 17:103340. doi: 10.1016/j.autrev.2023.103340. He had an 1 g/dL hemoglobin decrease on laboratory tests 3 days following his first vaccination. Zuin M, et al. Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know. The allogeneic HSCT replaces the recipient's hematopoietic and associated immune systems with those of the donor. An official website of the United States government. designed research, analyzed data, and wrote the manuscript; and all authors reviewed the manuscript and approved the final version. Aplastic Anemia. However, autoantibodies specific to AA and the role of autoantibodies for the pathogenesis of AA are unclear. Patient 3 is a 32-year-old woman with a 10-year history of PNH on ravulizumab with her last dose 4 weeks prior to vaccination. Is there a particular reason why he is donating so frequently? Does Anemia Cause Weight Loss or Weight Gain. Anemia with COVID-19 may also increase the risk of death. The state of vaccine safety science: systematic reviews of the evidence. He experienced fatigue and darkening of his urine following his first dose of the Moderna vaccine. Aplastic anemia can be treated with medications, blood transfusions, and even bone marrow stem cell transplants. I am not aware of any reports of iron depletion in the blood post Pfizer vaccine and when doing a quick search for information, did not come up with any either. Patient 1 is a 25-year-old man diagnosed with PNH 6 months prior in the setting of hemoglobinuria and had limited disease manifestations not requiring PNH-directed therapy. Aplastic Anemia Studies have confirmed the safety and efficacy of the available SARS-CoV-2 vaccines. Covid-19 Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Panel B: H.E. How does COVID-19 affect you if you have anemia? Listing a study does not mean it has been evaluated by the U.S. Federal Government. See this image and copyright information in PMC. Visit. Chimerism analysis performed on day 29 after the HSCT revealed complete chimerism in the peripheral blood. If you donate a Power Red, you lose twice that amount, about 470 mg of iron. EDTA added to serum serves as an inhibitor of hemolysis. COVID-19 Vaccines Research has found that COVID-19 with anemia is associated with more severe symptoms in people hospitalized for COVID-19. Hematological abnormalities in COVID-19: A narrative review. 2021 Dec 22;9(3):e0096521. WebNow scheduling COVID-19 vaccine appointments for ages 12+ Schedule a vaccine appointment COVID-19 vaccine FAQs. They also have higher death rates. Sue. Lockard Conley Research Fellowship in Benign Hematology (G.F.G.). PMC My husband has never had any history of anemia or low iron. Bivalent boosters are available for people ages 6 months and older who have completed their COVID-19 vaccine primary series. Guidelines for the diagnosis and management of adult aplastic anaemia. Diet might not be enough to bring his levels to where they are healthy again. He received the", "My husband gives blood regularly. HHS Vulnerability Disclosure, Help Hemolytic anemia is when RBCs are destroyed faster than they can be replaced. As a library, NLM provides access to scientific literature. It found that having anemia was associated with about a 70% higher risk of short-term death. Approximately 12 hours after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine, she had a fever (39C) and rigors. 2021;62(10):1510-1514. doi: 10.11406/rinketsu.62.1510. Connect with thousands of patients and caregivers for support, practical information, and answers. Patients were identified based on self-report of receiving the vaccine. The Pfizer/BioNTech and Moderna vaccines that have proven so effective against Covid-19 use RNA the instructions our cells use to produce proteins. 2021 May 15;13(5):e15035. and transmitted securely. Vaccine efficacy and iron deficiency: an intertwined pair? I Have Sickle Cell Anemia Should I Get the COVID-19 Vaccine? 1 Although the pathophysiology underlying severe COVID19 remains poorly understood, accumulating evidence argues for hyperinflammatory The remaining 7 patients with preexisting autoimmune anemia developed hemolysis; five with Hb levels above 7 and recovery without any treatment; two had Hb levels below 7 and received the same treatment with full recovery and complete remission. Received 2021 Nov 12; Revised 2021 Dec 8; Accepted 2021 Dec 10. Sue. The remaining authors declare no competing financial interests. WebKey points about aplastic anemia. We report a case in which AA developed after the administration of a SARS-CoV-2 vaccine. The pathogenetic mechanisms by which vaccines cause the development of autoimmune disease are still unclear. Thank you for submitting a comment on this article. Heavy alcohol drinking is known to further aggravate anemia. ). Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. A 73-year-old male patient with a medical history of hypertension, diabetes mellitus on insulin therapy, hyperlipidemia, coronary artery bypass grafting, and iron deficiency anemia received the first dose of Pfizer-BioNTech COVID-19 vaccination on 21 st, 2021. Search for other works by this author on: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. 1998-2023 Mayo Foundation for Medical Education and Research. The most common adverse effects following the vaccination are flu-like symptoms such as soreness, fatigue, myalgia, headache, chills, fever, joint pain, nausea, muscle spasm, sweating, dizziness, flushing, feelings of relief, brain fogging, anorexia, localized swelling, decreased sleep quality, itching, tingling, diarrhea, nasal stuffiness, Anemia - What Is Anemia? | NHLBI, NIH - National Institutes of It is important to notice that patients with hemolytic autoimmune anemia secondary COVID-19 had severe relapse, event that support the mimicry mentioned lines above. We report a case of severe AA that arose after the administration of a COVID-19 vaccine doi: 10.7759/cureus.15035. Young N.S. Analysis of hematologic adverse events reported to a national surveillance system following COVID-19 bivalent booster vaccination. Patients 5 and 6 received both doses of the Pfizer-BioNTech BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine without clinical or laboratory signs of hemolysis. With COVID-19, its believed to occur due to an autoimmune effect or direct injury to RBCs, according to 2022 research. People with COVID-19 can develop anemia due to increased levels of inflammation in the body. Radwi M., Farsi S. A case report of acquired hemophilia following COVID-19 vaccine. If you have anemia with COVID-19, it could affect your recovery. For a short time, it reduces the risk of Histological findings of the bone marrow biopsy specimen at diagnosis. Iron and iron-related proteins in COVID-19. Seroresponse to SARS-CoV-2 Vaccines among Maintenance Dialysis Patients over 6 Months. Association of anemia and COVID-19 in hospitalized patients. (2022). Going to a Cleveland Clinic location? Although relapses were observed in the three kinds of patients, all with hemolytic component developed a drop in the hemoglobin levels, most of them needed treatment. I'm not sure if getting the Moderna vaccine was the cause, but for the first time in my 71 year life my RBC count, just tested, is below the lowest low range. The titers of antibodies against SARS-CoV-2 were measured before and after the HSCT to examine the association between the SARS-CoV-2 vaccine the patient received and the development of AA. After my doctor/lab tests came back, my hemoglobin / hemocrit / ferritin was extremely low, ferritin is "3" hemoglobin "9". We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). She missed 2 doses of danicopan immediately after her second vaccination due to concerns that the drug may interfere with vaccine potency; therefore, danicopan was not at therapeutic levels at the time of her reaction. The relationship between the messenger ribonucleic acid vaccine and hemolytic parameters. All five patients with autoimmune hemolytic anemia secondary to COVID-19 developed Hb levels below 7 with anemic symptoms and needed treatment as described. WebNow scheduling COVID-19 vaccine appointments for ages 12+ Schedule a vaccine appointment COVID-19 vaccine FAQs. The only change in has been receiving the vaccine. They often share similar symptoms but have different causes as well as different treatments and severity. Symptoms may include: Abnormal paleness or lack of color of the skin Irritability Lack of energy or tiring easily (fatigue) Increased heart rate (tachycardia) Sore or swollen tongue Enlarged spleen ). Additionally on danicopan; however, 2 doses were missed immediately following vaccination. 2021;384(5):403-416. However, it is possible that he had some other (possibly unrecognized) infection that caused this sometimes iron is depleted in the body while the system is fighting an infection. and transmitted securely. Thanks, I checked the VAERS data could not find any reports of iron deficiency after vaccine. COVID-19 Vaccine Type and Adverse Effects Following https://bioiron.org/news/iron-stories/normal-iron-hemoglobin-levels-covid19-vaccination.aspx Cureus. The introduction of SARS-CoV-2 vaccines has drastically reduced the transmission rate of the disease. After the patient's hematopoietic stem cells were replaced through HSCT, his AA improved despite the presence of anti-SARS-CoV-2 antibodies. ncbi.nlm.nih.gov/pmc/articles/PMC9263052/, niddk.nih.gov/health-information/blood-diseases/anemia-inflammation-chronic-disease, ncbi.nlm.nih.gov/pmc/articles/PMC7790728/, ncbi.nlm.nih.gov/pmc/articles/PMC8270514/, cdc.gov/coronavirus/2019-ncov/your-health/treatments-for-severe-illness.html, ncbi.nlm.nih.gov/pmc/articles/PMC9040401/, ncbi.nlm.nih.gov/pmc/articles/PMC8225287/, ncbi.nlm.nih.gov/pmc/articles/PMC8045618/, respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01546-2, ncbi.nlm.nih.gov/pmc/articles/PMC9289930/, ncbi.nlm.nih.gov/pmc/articles/PMC7461220/, ncbi.nlm.nih.gov/pmc/articles/PMC6536698/, ncbi.nlm.nih.gov/pmc/articles/PMC8628963/. Elsevier Public Health Emergency Collection, https://doi.org/10.1016/j.jaut.2021.102782, https://doi:10.1046/j.1365-2141.2000.02171.x, https://doi:10.1046/j.1365-2141.2001.03006-2.x, https://doi:10.1016/S1473-3099(20)30130-4, https://doi:10.1016/S0140-6736(03)14802-7, https://doi:10.1182/bloodadvances.2019000853. Ann Hematol. Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial. In late February, 2021, a prothrombotic syndrome was observed in a few individuals who received the ChAdOx1 CoV-19 vaccine (AstraZeneca, University of Oxford, and Serum Institute of India), an adenoviral vector-based vaccine. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Group 2 (delayed iron treatment) will receive iron treatment at study end. 2023 May-Jun;43:79-84. doi: 10.1016/j.ijmmb.2022.10.012. There have been case reports of de-novo aplastic anaemia after vaccination, but SARS-CoV-2 infection itself seems to pose the greatest risk for this occurring. She had a favorable clinical Aplastic anemia following varicella vaccine. Two messenger RNA (mRNA)-based vaccines that lead to transient expression of the SARS-CoV-2 spike protein are highly efficacious in preventing severe infection.6,7 Reactions to these vaccines are generally mild; however, increased complement amplification could theoretically lead to more severe effects in diseases like paroxysmal nocturnal hemoglobinuria (PNH), where blood cells lack complement regulatory proteins.8 Here, we describe significant adverse reactions to COVID-19 vaccines in 4 patients with PNH. A 2020 study included people who had mild to critical COVID-19. 2023 Apr;102(4):955-959. doi: 10.1007/s00277-023-05136-2. Searching PubMed for tinnitus and Covid-19 vaccine does yield a handful of case reports, allergies, an acoustic neuroma, other growths, anemia, The mRNA vaccines against SARS-CoV-2 have a novel mechanism of action. Going to a Cleveland Clinic location? Prognostic role of anemia in COVID-19 patients: A meta-analysis. vaccine Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy, Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19, Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition, Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine, How I treat paroxysmal nocturnal hemoglobinuria, SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2, Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome, Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor, Anti-complement treatment for paroxysmal nocturnal hemoglobinuria: time for proximal complement inhibition? The conditioning regimen consisted of 120mg/m2 fludarabine, 100mg/kg cyclophosphamide, 2.5mg/kg anti-thymocyte globulin, and 2Gy of total body irradiation. J. Hematol. For this reason, people with COVID-19 who have anemia typically have poorer outcomes. The overall effect is that there are fewer RBCs in your blood, which means that the organs and tissues of your body arent getting enough oxygen. Convalescent Plasma Some people with COVID-19 who are immunocompromised or are receiving immunosuppressive treatment may benefit from a treatment called convalescent plasma. However, no method for assessing the relationships between vaccines and the development of autoimmune diseases has been established. For general information, Learn About Clinical Studies. Lee E.J., Cines D.B., Gernsheimer T., Kessler C., Michel M., Tarantino M.D., et al. 2023 Feb 15;15(2):e35020. Introduction. Between December 2020 and June 2021 there were identified 53 patients with autoimmune hematological disease that completed SARS-Cov2 vaccination. Conflict-of-interest disclosure: R.A.B. Would you like email updates of new search results? Eur J Haematol. Autoimmune cytopenias can be trigger by vaccines and viral infections by involving molecular mimicry and circulating immune complexes, including SARS-Cov2. The gray boxes indicate the titers of antibodies against the SARS-CoV-2 spike protein (log scale). For example, it has been reported that vaccine-derived antibodies may exhibit structural similarities with autoantibodies [18,19]. We are a community of people living with a wide variety of conditions and diseases, trying to live our best lives, and to help each other along the way by sharing our experiences. On the evening after his first dose of the Pfizer-BioNTech vaccine, he experienced fever, headache, myalgia, and severe fatigue, which lasted 6 days. doi: 10.1128/Spectrum.00965-21. Nurse getting ready to administer a vaccine. HSCT, hematopoietic stem cell transplantation; N.A., not applicable; SARS-Cov-2, severe acute respiratory syndrome coronavirus 2. The measurement of vaccine antibody titers before and after allogeneic HSCT may provide a clue to the pathogenesis of vaccine-related autoimmune diseases. 2018;379:16431656. 8600 Rockville Pike When your child has aplastic anemia, their bodys bone marrow isnt making enough white and red blood cells or platelets (cells that help their blood clot). Weiss G, et al. Panel B: H.E. The Covid-19 vaccines are very good at reducing the risk of hospitalization and death for the person who gets vaccinated. Zhonghua Xue Ye Xue Za Zhi. The clonal expansion of effector T cells was also reported to occur following vaccination [20]. Autoimmune haemolytic anaemia and immune thrombocytopenia following SARS-CoV-2 and non-SARS-CoV-2 vaccination: 32Years of passive surveillance data. Histological findings of the bone marrow biopsy specimen at diagnosis. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. WebThe following are the most common symptoms of iron-deficiency anemia. He received the Pfizer vaccine in March. The CDC recommends one bivalent booster dose: For everyone ages 5 years and older if it Tinnitus has been reported in individuals whove contracted COVID-19. In conclusion, the administered SARS-CoV-2 mRNA vaccine may have contributed to the pathogenesis of AA in this case. Disclaimer. Its unclear if and how anemia affects people with milder COVID-19 symptoms who dont require hospitalization. -. Vaccination and autoimmune disease: what is the evidence? doi: 10.7759/cureus.35020. Anemia of inflammation is typically addressed by treating the condition thats causing the anemia. The donor had no history of COVID-19 infection and had not received a SARS-CoV-2 vaccine. Some of the general symptoms of anemia are: Iron is a vital part of the hemoglobin thats present on RBCs. People with Certain Medical Conditions | CDC Panel A: Hematoxylin and eosin (H.E.) There are two main types of thalassemia: alpha and beta. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients performance: A prospective observational cohort study. Nitahara Y, Nakagama Y, Kaku N, Candray K, Michimuko Y, Tshibangu-Kabamba E, Kaneko A, Yamamoto H, Mizobata Y, Kakeya H, Yasugi M, Kido Y. Microbiol Spectr. Written consent for publication was obtained from the patient. S1 did not increase hemolysis of PNH erythrocytes as compared with aNHS alone (Figure 1). They can include: Anemia can happen with COVID-19, typically due to increased levels of inflammation in the body. Written consent for publication was obtained from the patient. Characteristics of COVID-19 Citizen Science Study Participants eTable 2. Heavy and prolonged menstrual bleeding between or during periods. (2020). Discussion of the hematologic complications of vaccination for severe acute respiratory syndrome coronavirus-2 (COVID-19) has primarily focused on the development of vaccine-associated immune thrombosis with thrombocytopenia (VITT). COVID-19 and Anemia: How They're Related? - Healthline Before We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). Rehabilitation Committee of Hematological Diseases, Chinese Association of Rehabilitation Medicine;; Chinese Society of Hematology, Chinese Medical Association. COVID-19 can lead to a variety of blood-related issues, including blood clots and changes in white blood cell or platelet counts. Symptoms. The only change in has been receiving the vaccine. Please check for further notifications by email. To treat the low blood counts, early treatment involves easing symptoms. [Chinese consensus on severe acute respiratory syndrome coronavirus-2 vaccination in adult patients with hematological diseases (2023)]. Can you start by sharing more about why this is of interest to you to perhaps bring in other members who may be able to relate? sharing sensitive information, make sure youre on a federal WebIt measures white and red blood cells, platelets, hemoglobin (cells that carry oxygen) and hematocrit (volume of red blood cells). The online version of this article contains a data supplement. If you have anemia, your body does not get Among patients with SARSCoV2 infection (also known as COVID19), pneumonia, respiratory failure and acute respiratory distress syndrome are frequently encountered complications. COVID-19: Who's at higher risk of serious symptoms? pharmacytimes.com A growing number of studies now suggest that people with this painful genetic blood disorder who also are infected with SARS-CoV-2, the virus that causes COVID-19 disease, are more vulnerable to severe health complications than the rest of the population. Donnini I., Scappini B., Guidi S., Longo G., Bosi A. If anemia is severe or left untreated, it can lead to serious or life threatening complications. Women in both groups will receive the 1st dose of the COVID-19 vaccine. Ashok Shenoy K., Prabha Adhikari M.R., Chakrapani M., Shenoy D., Pillai A. Pancytopenia after recombinant hepatitis B vaccine--an Indian case report. HHS Vulnerability Disclosure, Help Rinsho Ketsueki. Anemia is associated with severe illness in COVID‐19: A retrospective cohort study. Killick S.B., Bown N., Cavenagh J., Dokal I., Foukaneli T., Hill A., et al. 2022;63(9):1067-1077. doi: 10.11406/rinketsu.63.1067. Anemia Four of 6 patients reported fever. Its important to note that most of the research into outcomes for COVID-19 and anemia has been done in hospitalized individuals. My husband's various blood levels also declined after the vaccine. Yes. Various cases of vaccine-related autoimmune disease have been reported. However, each individual may experience symptoms differently. Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan. Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. the contents by NLM or the National Institutes of Health. Good afternoon and welcome to Mayo Connect. Research has found that anemia is associated with a poorer outlook in people who have COVID-19. They are going to try the camera endoscopy next week. [COVID-19 vaccination for allogeneic hematopoietic stem cell recipients]. My husband has never had any history of anemia or low iron. We recommend vaccination within 4 weeks of the last ravulizumab infusion and 1 week of eculizumab infusion and that patients maintain optimal hydration. 2022 Dec;133:102915. doi: 10.1016/j.jaut.2022.102915. Vaccine response will be measured 28 and 56 days after the first vaccine administration in both groups. Severe aplastic anemia after COVID-19 mRNA vaccination: 2023 Jan 14;44(1):19-25. doi: 10.3760/cma.j.issn.0253-2727.2023.01.004. Can you develop anemia because of COVID-19? Hemasphere. Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. mRNA-1345 is a single messenger RNA (mRNA) sequence encoding for a stabilized prefusion F glycoprotein, using the same lipid nanoparticles as the companys The allogeneic BMT was conducted at 34 days after the 2nd dose of the COVID-19 vaccine was administered. Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity? Use VaxFinder to search for appointments. Adult patients 18 years or older with autoimmune thrombocytopenia, Evans syndrome and autoimmune hemolytic anemia who completed SARS-Cov2 vaccination. doi: https://doi.org/10.1182/blood.2021011548. The FDA has approved the Moderna vaccine, now To be approved, the vaccines must go through a careful trial process with several phases to address safety and effectives. I also couldn't find anything that suggests a link between Pfizer vaccines and low iron. Thank you for submitting a comment on this article. All rights reserved. Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. Further studies are needed to investigate the impairment of hematopoiesis induced by immune reactions after SARS-CoV-2 vaccine administration. Choosing to participate in a study is an important personal decision. Rahman A, et al. Twelve with autoimmune hemolytic anemia, 5 secondaries to previous COVID-19 and 7 preexisting. Shah C., Lemke S., Singh V., Gentile T. Case reports of aplastic anemia after vaccine administration. COVID; COVID vaccine; autoimmune hemolytic anemia; hematology oncology; hemolysis; rheumatology. The Coronavirus Disease 2019 (COVID-19) pandemic has affected the entire globe. All Rights Reserved. The vaccine developers report that some people experience pain where they were injected; body aches; headaches or fever, COVID-19 Vaccine Panel A: Hematoxylin, Evaluation of neutrophil count, The X-axis indicates the number of days after the, MeSH Information provided by (Responsible Party): Prof Simon Karanja, Jomo Kenyatta University of Agriculture and Technology. Yes. Kayukawa S, Nanya K, Morita M, Ina K, Ota Y, Hasegawa S. Microbiol Spectr. Insights into new-onset autoimmune diseases after COVID-19 vaccination. 2023 Healthline Media LLC. MeSH COVID-19 Ten patients had a fall of 50 % from basal counts and recovered spontaneously. Can You Get a COVID Vaccine If You Have Beta Thalassemia? Covid-19 8600 Rockville Pike Five days after receiving the second dose of the Pfizer-BioNTech vaccine, he developed abdominal pain leading to evaluation in an emergency department. Careers. Read our, ClinicalTrials.gov Identifier: NCT04915820, Interventional The https:// ensures that you are connecting to the Iron-Deficiency Anemia However, rare cases of adverse immunological reactions to SARS-CoV-2 vaccines have been reported, including cases involving immune-mediated disease [[1], [2], [3]]. Various cases of autoimmune disease have been reported after SARS-CoV-2 vaccine administration, including autoimmune hepatitis, type 1 diabetes mellitus, immune thrombocytopenia, and acquired hemophilia [3,[13], [14], [15]]. As a result, theres less iron available for hemoglobin on new RBCs. A coordinator will follow up to see if Mayo Clinic is right for you. Older age, Black or African American race, higher subjective social status, asthma, and anemia were associated with lower odds of reporting adverse Careers. N Engl J Med. (2018). He received the Pfizer vaccine and his blood which has never been low in iron was low in iron. Anemia can also happen with COVID-19. Further evaluations in large cohorts are warranted to elucidate the associations between AA and SARS-CoV-2 vaccines. My husband has never had any history of anemia or low iron. If I were you I'd encourage him to get a complete blood panel and have the doctor help with low iron.
